Szolnoki Zoltan, Szekeres Marta, Szaniszlo Istvan, Balda Gyorgy, Bodor Anita, Kondacs Andras, Mandi Yvette, Somogyvari Ferenc
Department of Cerebrovascular Diseases, Pándy Kálmán County Hospital, Gyula, Hungary.
Department of Medical Microbiology and Immunology, Faculty of Medicine, University of Szeged, Szeged, Hungary.
Arch Med Res. 2015 Nov;46(8):604-8. doi: 10.1016/j.arcmed.2015.11.002. Epub 2015 Nov 11.
Leukoaraiosis (LA), one of the most frequent causes of an age-associated cognitive decline, can be associated with a poor quality of life, leading overall to far-reaching public health problems. Chronic hypoxia of the white matter of the brain may be a factor triggering this entity. LA may develop as a consequence of chronically insufficient cellular energy production and the accumulation of free radicals.
In this context, after hypothesizing that the number of healthy mitochondria can be crucial in this complex process, a case-control LA study was carried out in which we analyzed the numbers of deleted and non-deleted mitochondria (the common D-loop deletion) per white blood cell. A total of 234 patients with LA and 123 MRI alteration-free subjects served as a control group.
Interestingly, it emerged that the ratio of deleted relative to non-deleted mitochondria is strongly associated with the risk of LA. The calculated K ratio in the LA group was significantly lower than the K ratio in the controls (LA: K 0.37 95% CI 0.05; controls: K 0.48, 95% CI 0.076, p < 0.001).
Our study suggests that the ratio of the dmDNA and mDNA can be of great importance in the pathogenesis of LA.
脑白质疏松症（LA）是与年龄相关的认知衰退最常见的病因之一，可能与生活质量差相关，总体上导致深远的公共卫生问题。脑白质的慢性缺氧可能是引发这一病症的一个因素。LA可能是细胞能量长期产生不足和自由基积累的结果。
在此背景下，在假设健康线粒体的数量在这一复杂过程中可能至关重要后，开展了一项LA病例对照研究，我们分析了每个白细胞中缺失和未缺失的线粒体（常见的D环缺失）数量。共有234例LA患者和123例无MRI改变的受试者作为对照组。
有趣的是，结果显示缺失线粒体与未缺失线粒体的比例与LA风险密切相关。LA组计算出的K比例显著低于对照组的K比例（LA组：K 0.37，95%置信区间0.05；对照组：K 0.48，95%置信区间0.076，p < 0.001）。
我们的研究表明，dmDNA与mDNA的比例在LA的发病机制中可能非常重要。
