Wang Bijia, Li Xuegang, Li Haoyi, Xiao Li, Zhou Zhenhua, Chen Kangning, Gui Li, Hou Xianhua, Fan Rong, Chen Kang, Wu Wenjing, Li Haitao, Hu Xiaofei
Department of Neurology, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Department of Neurosurgery, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Front Neurol. 2022 Jun 24;13:841521. doi: 10.3389/fneur.2022.841521. eCollection 2022.
Cerebral small vessel disease (CSVD) and multiple sclerosis (MS) are a group of diseases associated with small vessel lesions, the former often resulting from the vascular lesion itself, while the latter originating from demyelinating which can damage the cerebral small veins. Clinically, CSVD and MS do not have specific signs and symptoms, and it is often difficult to distinguish between the two from the aspects of the pathology and imaging. Therefore, failure to correctly identify and diagnose the two diseases will delay early intervention, which in turn will affect the long-term functional activity for patients and even increase their burden of life. This review has summarized recent studies regarding their similarities and difference of the clinical manifestations, pathological features and imaging changes in CSVD and MS, which could provide a reliable basis for the diagnosis and differentiation of the two diseases in the future.
脑小血管病（CSVD）和多发性硬化症（MS）是一组与小血管病变相关的疾病，前者常由血管病变本身引起，而后者源于可损害脑小静脉的脱髓鞘病变。临床上，CSVD和MS没有特异性的体征和症状，从病理学和影像学方面往往难以区分两者。因此，不能正确识别和诊断这两种疾病会延误早期干预，进而影响患者的长期功能活动，甚至增加其生活负担。本综述总结了近期关于CSVD和MS在临床表现、病理特征和影像学变化方面异同的研究，可为未来这两种疾病的诊断和鉴别提供可靠依据。
