经会阴间质前列腺近距离治疗后使用松散种子源导致的种子迁移：日本前列腺癌永久性碘-125种子植入结局研究（J-POPS）多机构队列研究。
Seed migration after transperineal interstitial prostate brachytherapy by using loose seeds: Japanese prostate cancer outcome study of permanent iodine-125 seed implantation (J-POPS) multi-institutional cohort study.
作者信息
Nakano Masahiro, Yorozu Atsunori, Saito Shiro, Sugawara Akitomo, Maruo Shinichiroh, Kojima Shinsuke, Kikuchi Takashi, Fukushima Masanori, Dokiya Takushi, Yamanaka Hidetoshi
机构信息
Department of Urology, Gifu University Graduate School of Medicine, 1-1Yanagito, Gifu-shi, Gifu, 501-1194, Japan.
Department of Radiation Oncology, National Hospital Organization, Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo, 152-8902, Japan.
出版信息
Radiat Oncol. 2015 Nov 14;10:228. doi: 10.1186/s13014-015-0532-3.
BACKGROUND
The incidence and associated factors of loose seed migration were investigated in cohort 1 of the Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 Seed Implantation (J-POPS).
METHODS
The study subjects were 2160 patients, consisting of 1641 patients who underwent permanent iodine-125 seed implantation (PI) and 519 patients who underwent PI combined with external beam radiation therapy (PI + EBRT). The presence or absence of seed migration to the chest and abdominal/pelvic region was determined.
RESULTS
Seed migration was observed in 22.7 % of PI group patients and 18.1 % of PI + EBRT group patients (p = 0.0276). Migration to the lungs and abdominal/pelvic region was observed in 14.6 % and 11.1 % of the patients in the PI group, and 11.2 % and 8.5 % of the patients in the PI + EBRT group, respectively. In the PI group, the number of implanted seeds was associated with the seed migration incidence. Neither the PI nor the PI + EBRT group showed any difference in the volume of the prostate receiving 100 % of the prescribed dose (V100 [%]) or the minimal dose received by 90 % of the prostate volume (D90 [Gy]) between the patients with and without seed migration.
CONCLUSIONS
This prospective cohort study investigating the largest number of past cases showed no difference in D90 (Gy) or V100 (%) between seed migration or the absence thereof in both the PI group and PI + EBRT group.
TRIAL REGISTRATION
ClinicalTrials.gov: NCT00534196.
背景
在日本永久性碘 - 125粒子植入前列腺癌结局研究（J - POPS）队列1中，研究了粒子迁移的发生率及相关因素。
方法
研究对象为2160例患者，其中1641例接受永久性碘 - 125粒子植入（PI），519例接受PI联合外照射放疗（PI + EBRT）。确定粒子是否迁移至胸部及腹部/盆腔区域。
结果
PI组患者中22.7%观察到粒子迁移，PI + EBRT组患者中18.1%观察到粒子迁移（p = 0.0276）。PI组分别有14.6%和11.1%的患者粒子迁移至肺部和腹部/盆腔区域，PI + EBRT组分别有11.2%和8.5%的患者粒子迁移至肺部和腹部/盆腔区域。在PI组，植入粒子数量与粒子迁移发生率相关。PI组和PI + EBRT组中，有粒子迁移和无粒子迁移的患者之间，接受100%处方剂量的前列腺体积（V100 [%]）或90%前列腺体积接受的最小剂量（D90 [Gy]）均无差异。
结论
这项调查既往病例数最多的前瞻性队列研究表明，PI组和PI + EBRT组中，粒子迁移与否在D90（Gy）或V100（%）方面均无差异。
试验注册
ClinicalTrials.gov：NCT00534196。
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