Sajid Muhammad Tanveer, Mustafa Qurat ul Ain, Shaheen Neelofar, Hussain Syed Mukarram, Shukr Irfan, Ahmed Muhammad
Department of General Surgery, Combined Military Hospital, Rawalpindi.
J Coll Physicians Surg Pak. 2015 Nov;25(11):789-93.
To evaluate the clinical efficacy of Negative Pressure Wound Therapy (NPWT) using Vacuum Assisted Closure (VAC) compared with Advanced Moist Wound Therapy (AMWT) to treat Diabetic Foot Ulcer (DFU).
Randomized control trial.
Surgical Department, Combined Military Hospital (CMH) / Military Hospital (MH), Rawalpindi, from November 2010 to June 2012.
The study consisted of 278 patients, with 139 patients each in Group 'A' and 'B', who were subjected to AMWT and NPWT, respectively. Wound was assessed digitally every week for 2 weeks. Wound dimension and surface area were determined using University of Texas Health Centre at San Antonio (UTHCSA) image tool version 3.0. Efficacies of AMWT and NPWT were compared in terms of reduction in wound area over 2 weeks.
Mean age of presentation in group A was 55.88 ± 10.97 years while in group B, it was 56.83 ± 11.3 (p=0.48). Mean duration of diabetes at presentation was 15.65 ± 4.86 and 15.96 ± 5.79 years in group A and B, respectively (p=0.74). Majority of patients had Wagner's grade 2 ulcer (82% in group A and 87.8% in group B, p= 0.18). Initial wound size in group A was 15.07 ± 2.92 cm2 and in group B 15.09 ± 2.81 cm2 (p = 0.95). Wound size measured after 2 weeks, treatment was in group A13.70 ± 2.92 cm2 and in group B 11.53 ± 2.78 cm2 (p < 0.001). Wound area reduction in both groups revealed statistically significant faster healing in group B as compared to group A (p < 0.001).
NPWT using VAC was more efficacious than AMWT in the management of diabetic foot ulcers.
评估采用真空辅助闭合（VAC）的负压伤口治疗（NPWT）与先进湿性伤口治疗（AMWT）相比，治疗糖尿病足溃疡（DFU）的临床疗效。
随机对照试验。
2010年11月至2012年6月，拉瓦尔品第联合军事医院（CMH）/军事医院（MH）外科。
该研究包括278例患者，A组和B组各139例，分别接受AMWT和NPWT治疗。每周对伤口进行数字化评估，持续2周。使用圣安东尼奥德克萨斯大学健康中心（UTHCSA）图像工具3.0版确定伤口尺寸和表面积。比较AMWT和NPWT在2周内伤口面积减少方面的疗效。
A组患者的平均就诊年龄为55.88±10.97岁，B组为56.83±11.3岁（p = 0.48）。A组和B组患者就诊时糖尿病的平均病程分别为15.65±4.86年和15.96±5.79年（p = 0.74）。大多数患者患有瓦格纳2级溃疡（A组为82%，B组为87.8%，p = 0.18）。A组初始伤口大小为15.07±2.92平方厘米，B组为15.09±2.81平方厘米（p = 0.95）。治疗2周后测量的伤口大小，A组为13.70±2.92平方厘米，B组为11.53±2.78平方厘米（p < 0.001）。两组伤口面积减少情况显示，与A组相比，B组愈合速度在统计学上明显更快（p < 0.001）。
在糖尿病足溃疡的治疗中，采用VAC的NPWT比AMWT更有效。
