氯丙嗪对大鼠异相睡眠的双相作用：剂量相关机制的研究。

Biphasic effect of chlorpromazine on rat paradoxical sleep: a study of dose-related mechanisms.

作者信息

Kafi S, Gaillard J M

出版信息

Eur J Pharmacol. 1978 Jun 1;49(3):251-7. doi: 10.1016/0014-2999(78)90100-0.

Abstract

The experiments reported here investigated the effect of chlorpromazine (CPZ) alone or after inhibition of catecholamine (CA) synthesis on paradoxical sleep (PS) in the rat. The dose--response curve for CPZ was biphasic with enhancement of PS after low doses, and depression of PS after higher doses. In contrast, low doses of CPZ after inhibition of CA synthesis markedly decreased PS. This decrease was greater after tyrosine hydroxylase inhibition than after dopamine-beta-hydroxylase inhibition. These results support the view that low doses of CPZ produce increased activity in brain CA synapses, and that both dopamine and noradrenaline participate in the control of PS in the rat.

摘要

本文报道的实验研究了单独使用氯丙嗪（CPZ）或抑制儿茶酚胺（CA）合成后对大鼠异相睡眠（PS）的影响。CPZ的剂量-反应曲线呈双相性，低剂量时PS增强，高剂量时PS抑制。相比之下，抑制CA合成后低剂量的CPZ显著降低PS。酪氨酸羟化酶抑制后这种降低比多巴胺-β-羟化酶抑制后更大。这些结果支持以下观点：低剂量的CPZ使脑内CA突触活性增加，并且多巴胺和去甲肾上腺素都参与大鼠PS的调控。