上皮性卵巢癌中的细胞外基质——拼图的一部分
The Extracellular Matrix in Epithelial Ovarian Cancer - A Piece of a Puzzle.
作者信息
Cho Angela, Howell Viive M, Colvin Emily K
机构信息
School of Medical and Molecular Biosciences, University of Technology Sydney , Sydney, NSW , Australia ; Bill Walsh Translational Cancer Research Laboratory, Kolling Institute, Northern Sydney Local Health District , St. Leonards, NSW , Australia.
Bill Walsh Translational Cancer Research Laboratory, Kolling Institute, Northern Sydney Local Health District , St. Leonards, NSW , Australia ; Sydney Medical School Northern, University of Sydney , Sydney, NSW , Australia.
出版信息
Front Oncol. 2015 Nov 2;5:245. doi: 10.3389/fonc.2015.00245. eCollection 2015.
Epithelial ovarian cancer is the fifth leading cause of cancer-related deaths in women and the most lethal gynecological malignancy. Extracellular matrix (ECM) is an integral component of both the normal and tumor microenvironment. ECM composition varies between tissues and is crucial for maintaining normal function and homeostasis. Dysregulation and aberrant deposition or loss of ECM components is implicated in ovarian cancer progression. The mechanisms by which tumor cells induce ECM remodeling to promote a malignant phenotype are yet to be elucidated. A thorough understanding of the role of the ECM in ovarian cancer is needed for the development of effective biomarkers and new therapies.
上皮性卵巢癌是女性癌症相关死亡的第五大主要原因，也是最致命的妇科恶性肿瘤。细胞外基质（ECM）是正常和肿瘤微环境的重要组成部分。ECM的组成因组织而异，对于维持正常功能和体内平衡至关重要。ECM成分的失调、异常沉积或缺失与卵巢癌的进展有关。肿瘤细胞诱导ECM重塑以促进恶性表型的机制尚待阐明。为了开发有效的生物标志物和新疗法，需要深入了解ECM在卵巢癌中的作用。
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