Li Zhigang, Peres Adam G, Damian Andreea C, Madrenas Joaquín
Microbiome and Disease Tolerance Center, Department of Microbiology and Immunology, McGill University, Montréal, QC, H3A 2B4, Canada.
Pathogens. 2015 Nov 13;4(4):793-815. doi: 10.3390/pathogens4040793.
The Gram-positive bacterium Staphylococcus aureus is one of the most frequent pathogens that causes severe morbidity and mortality throughout the world. S. aureus can infect skin and soft tissues or become invasive leading to diseases such as pneumonia, endocarditis, sepsis or toxic shock syndrome. In contrast, S. aureus is also a common commensal microbe and is often part of the human nasal microbiome without causing any apparent disease. In this review, we explore the immunomodulation and disease tolerance mechanisms that promote commensalism to S. aureus.
革兰氏阳性菌金黄色葡萄球菌是全球范围内导致严重发病和死亡的最常见病原体之一。金黄色葡萄球菌可感染皮肤和软组织，或侵入人体引发肺炎、心内膜炎、败血症或中毒性休克综合征等疾病。相比之下，金黄色葡萄球菌也是一种常见的共生微生物，常作为人类鼻腔微生物群的一部分而不引发任何明显疾病。在本综述中，我们探讨了促进与金黄色葡萄球菌共生的免疫调节和疾病耐受机制。
