Calabrese L H
Department of Rheumatic and Immunologic Disease, Cleveland Clinic Foundation 44195-5028.
Semin Arthritis Rheum. 1989 May;18(4):225-39. doi: 10.1016/0049-0172(89)90043-7.
The recognized clinical spectrum of disease associated with HIV infection is rapidly expanding and now includes a variety of rheumatic syndromes. The laboratory features of HIV infection closely resemble those found in many connective tissue diseases and thus alter the predictive value of these tests in the evaluation of both types of conditions. In addition to the laboratory similarities, there are also increasing numbers of clinical reports of HIV-infected individuals who develop syndromes either resembling classic idiopathic rheumatic diseases such as SS, polymyositis, or SLE, or newly recognized illnesses that fall under the clinical domain of the rheumatologist (ie, HIV-associated vasculitis and arthritis). It is vital that clinicians recognize these new illnesses because there are important differences in prognosis and management between these and their idiopathic counterparts. Research is urgently needed for better definition of these syndromes and their pathogenesis, natural history, and optimal therapies.
与HIV感染相关的公认临床疾病谱正在迅速扩大，现在包括多种风湿综合征。HIV感染的实验室特征与许多结缔组织疾病的特征极为相似，从而改变了这些检测在评估这两类疾病时的预测价值。除了实验室特征相似外，越来越多的临床报告显示，HIV感染者会出现类似经典特发性风湿疾病（如干燥综合征、多发性肌炎或系统性红斑狼疮）的综合征，或属于风湿病学家临床范畴的新确认疾病（即HIV相关血管炎和关节炎）。临床医生认识到这些新疾病至关重要，因为这些疾病与其特发性对应疾病在预后和管理方面存在重要差异。迫切需要开展研究，以更好地界定这些综合征及其发病机制、自然史和最佳治疗方法。
