Moirand R, Lescoat G, Brissot P
INSERM U 49. Unité de Recherches Hépatologiques, Hôpital Pontchaillou, Rennes.
Ann Gastroenterol Hepatol (Paris). 1989 Mar-Apr;25(2):51-4.
The known relationship between ethanol and the two main proteins of iron metabolism, transferrin and ferritin, are reviewed. Transferrin synthesis decreases in alcoholic cirrhosis, and increases in alcoholic fatty liver. In the latter case, its turnover is accelerated. Serum desialylated transferrin increases in chronic alcoholism and could be the best marker of heavy drinking. The increased uptake of desialylated transferrin by the liver could explain the development of hepatic siderosis in some alcoholics. Serum ferritin increases in chronic alcoholism, much more because of liver damage than in relation to iron stores. It is clear in this review that few experimental studies have been interested in the investigation of these relationships.
本文综述了乙醇与铁代谢的两种主要蛋白质——转铁蛋白和铁蛋白之间的已知关系。在酒精性肝硬化中，转铁蛋白合成减少，而在酒精性脂肪肝中则增加。在后一种情况下，其周转率加快。慢性酒精中毒时血清去唾液酸转铁蛋白增加，可能是大量饮酒的最佳标志物。肝脏对去唾液酸转铁蛋白摄取增加可能解释了一些酗酒者肝铁沉着症的发生。慢性酒精中毒时血清铁蛋白增加，更多是由于肝脏损伤而非铁储存。在本综述中很明显，很少有实验研究关注这些关系的调查。
