Molitch M E
Center for Endocrinology, Metabolism, and Nutrition, Northwestern University Medical School, Chicago, Illinois 60611.
Annu Rev Med. 1989;40:225-32. doi: 10.1146/annurev.me.40.020189.001301.
Prolactinomas are the most common of the hormone-secreting pituitary tumors and must be distinguished from nonsecreting tumors causing hyperprolactinemia by hypothalamic or stalk dysfunction. For both micro- and macroadenomas, dopamine agonists appear to be the treatment of choice, transsphenoidal surgery being reserved for nonresponders. For women desiring pregnancy, dopamine agonists are safe when there is a microadenoma or an intrasellar macroadenoma. However, in women with large macroadenomas desiring pregnancy, limited transsphenoidal decompression followed by bromocriptine appears to be the safest mode of treatment.
泌乳素瘤是最常见的分泌激素的垂体肿瘤，必须与因下丘脑或垂体柄功能障碍导致高泌乳素血症的无分泌功能肿瘤相鉴别。对于微腺瘤和大腺瘤，多巴胺激动剂似乎是首选治疗方法，经蝶窦手术则保留用于无反应者。对于渴望怀孕的女性，当存在微腺瘤或鞍内大腺瘤时，多巴胺激动剂是安全的。然而，对于渴望怀孕的大腺瘤女性，有限的经蝶窦减压后使用溴隐亭似乎是最安全的治疗方式。
