直接催化不对称合成β-羟基酸从丙二酸。

Direct Catalytic Asymmetric Synthesis of β-Hydroxy Acids from Malonic Acid.

机构信息

College of Chemistry and Materials Engineering, Wenzhou University , Wenzhou, Zhejiang Province P.R. China.

出版信息

Org Lett. 2015 Dec 18;17(24):5962-5. doi: 10.1021/acs.orglett.5b02891. Epub 2015 Nov 20.

DOI:10.1021/acs.orglett.5b02891

Abstract

A nickel(II) catalyzed asymmetric synthesis of β-hydroxy acids from malonic acid and ketones was developed, revealing for the first time the synthetic utility of malonic acid in the construction of chiral carboxyl acids; importantly, the synthetic potential of this strategy was further demonstrated by the rapid construction of cephalanthrin A, phaitanthrin B, cruciferane, and rice metabolites.

摘要

发展了一种镍（II）催化的由丙二酸和酮不对称合成β-羟基酸的方法，首次揭示了丙二酸在构建手性羧酸中的合成应用；重要的是，该策略的合成潜力通过快速构建贝壳杉烯 A、石蒜碱 B、 cruciferane 和水稻代谢物得到了进一步证明。