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原发性喉声门恶性黑色素瘤(PGMML):一种非常罕见的疾病。

Primary glottic malignant melanoma of the larynx (PGMML): a very rare entity.

作者信息

Aggarwal Sumeet, Kaushal Vivek, Singla Sujata, Sen Rajeev

机构信息

Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.

Department of Radiation Oncology, Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.

出版信息

BMJ Case Rep. 2015 Nov 20;2015:bcr2015211317. doi: 10.1136/bcr-2015-211317.

Abstract

Primary glottic malignant melanoma of the larynx (PGMML) is a very rare clinical entity with less than 20 cases reported in the literature so far. The most frequently reported subsite in primary malignant melanomas of the larynx is the supraglottic larynx. The vocal cord as a subsite for primary malignant melanoma is very rare. The present case is a primary glottic malignant melanoma involving both vocal cords. PGMML may present early due to associated hoarseness of voice, unlike other non-cutaneous melanomas in the head and neck. Non-cutaneous malignant melanomas in the head and neck are historically very aggressive in nature and known for poor outcomes and survival. Most non-cutaneous melanomas described in the literature have been superficial spreading or ulcerative in nature, unlike the present case, in which proliferative, polypoidal growth was seen. No associated risk factor was present in this case. Every reported case of this rare entity further adds to the better understanding of tumour biology and expression.

摘要

原发性喉声门恶性黑色素瘤(PGMML)是一种非常罕见的临床实体,迄今为止文献报道的病例不足20例。喉原发性恶性黑色素瘤最常报道的亚部位是声门上区。声带作为原发性恶性黑色素瘤的亚部位非常罕见。本病例是一例累及双侧声带的原发性声门恶性黑色素瘤。与头颈部其他非皮肤黑色素瘤不同,PGMML可能因伴有声音嘶哑而早期出现。历史上,头颈部非皮肤恶性黑色素瘤本质上具有很强的侵袭性,预后和生存率较差。文献中描述的大多数非皮肤黑色素瘤本质上为浅表扩散型或溃疡型,与本病例不同,本病例可见增生性、息肉样生长。该病例不存在相关危险因素。每例报道的这种罕见实体病例都有助于更好地理解肿瘤生物学和表达。

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