脂多糖诱导培养的肝细胞单层产生胰岛素抵抗。
Lipopolysaccharide-induced insulin resistance in monolayers of cultured hepatocytes.
作者信息
Portolés M T, Pagani R, Ainaga M J, Díaz-Laviada I, Municio A M
机构信息
Department of Biochemistry & Molecular Biology I, Faculty of Chemistry, Universidad Complutense, Madrid, Spain.
出版信息
Br J Exp Pathol. 1989 Apr;70(2):199-205.
Abstract
In order to clarify the endotoxin effect on the hepatic removal of insulin, the influence of lipopolysaccharide (LPS) from E. coli 0111:B4 on the insulin binding and endocytosis in cultured hepatocytes from adult male rats has been investigated. LPS decreases both processes in a time and temperature-dependent manner, showing a major effect at short time and low temperature, according to the characteristics of LPS binding and uptake.
摘要
为了阐明内毒素对肝脏清除胰岛素的影响，研究了来自大肠杆菌0111:B4的脂多糖（LPS）对成年雄性大鼠培养肝细胞中胰岛素结合和内吞作用的影响。根据LPS结合和摄取的特性，LPS以时间和温度依赖性方式降低这两个过程，在短时间和低温下显示出主要作用。
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