Showel Margaret, Fuchs Ephraim J
Division of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 289 Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21287, USA.
Division of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 289 Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21287, USA.
Best Pract Res Clin Haematol. 2015 Jun-Sep;28(2-3):141-6. doi: 10.1016/j.beha.2015.10.011. Epub 2015 Oct 22.
While allogeneic hematopoietic stem cell transplantations have a curative potential, several patients with hematologic malignancies cannot avail themselves of this therapeutic option due to lack of matched donor availability. Although HLA-haploidentical transplantations were previously associated with poor outcomes, recent evidence with use of post transplantation cyclophosphamide indicate improved safety and efficacy. The following paper discusses the most recent developments in this area.
虽然异基因造血干细胞移植具有治愈潜力，但由于缺乏匹配的供体，一些血液系统恶性肿瘤患者无法采用这种治疗选择。尽管HLA单倍型相合移植以前与不良预后相关，但最近使用移植后环磷酰胺的证据表明安全性和疗效有所改善。以下论文讨论了该领域的最新进展。
