De Souza Ferreira Sabrina Barbosa, Moço Talita Dias, Borghi-Pangoni Fernanda Belincanta, Junqueira Mariana Volpato, Bruschi Marcos Luciano
Postgraduate Program in Pharmaceutical Sciences, Maringá, Paraná, Brazil; Laboratory of Research and Development of Drug Delivery Systems, Maringá, Paraná, Brazil.
Laboratory of Research and Development of Drug Delivery Systems, Maringá, Paraná, Brazil.
J Mech Behav Biomed Mater. 2015 Mar;55:164-178. doi: 10.1016/j.jmbbm.2015.10.026. Epub 2015 Nov 10.
The development of binary polymeric mixtures (polymer blends) containing bioadhesive and thermoresponsive polymers can provide new materials for biomedical applications, with higher contact, increased adhesion, prolonged residence time, protection, and in determined cases, secured absorption of an active agent from the site of application. Mixtures were prepared using a wide range of poloxamer 407 and Carbopol 971P(®) amounts. The rheological (flow and oscillatory), sol-gel transition temperature, mechanical (hardness, compressibility, adhesiveness, cohesiveness and elasticity), softness, and mucoadhesive properties of formulations were investigated. Moreover, the interaction between the different proportions of polymers was also analyzed. Continuous shear and oscillatory rheometry identified the plastic flow with various degrees of thixotropy, besides the viscoelastic behavior of formulations. The determination of gelation temperature displayed values ranged from 27.17 to 41.09°C. It was also found that low carbomer concentrations were enough to provide positive interaction parameter. However, the highest values were obtained for the polymeric blends with higher concentration of poloxamer 407. The mucoadhesion and softness index were greater in preparations containing 20% (w/w) poloxamer 407. The rheological, mechanical and mucoadhesive properties of the polymeric blends can be manipulated by changing the concentrations of the polymers and they suggest the blends are worthy of biomedical applications.
含有生物黏附性和热响应性聚合物的二元聚合物混合物（聚合物共混物）的开发可为生物医学应用提供新材料，具有更高的接触性、增强的黏附性、延长的停留时间、保护作用，并且在特定情况下可确保活性剂从应用部位吸收。使用多种泊洛沙姆407和卡波姆971P（®）的量制备混合物。研究了制剂的流变学（流动和振荡）、溶胶-凝胶转变温度、机械性能（硬度、可压缩性、黏附性、内聚性和弹性）、柔软度和黏膜黏附性能。此外，还分析了不同比例聚合物之间的相互作用。连续剪切和振荡流变学确定了制剂除了具有黏弹性行为外，还具有不同程度触变性的塑性流动。凝胶化温度的测定显示值范围为27.17至41.09°C。还发现低卡波姆浓度足以提供正相互作用参数。然而，泊洛沙姆407浓度较高的聚合物共混物获得了最高值。在含有20%（w/w）泊洛沙姆407的制剂中，黏膜黏附性和柔软度指数更高。聚合物共混物的流变学、机械性能和黏膜黏附性能可以通过改变聚合物的浓度来控制，这表明这些共混物值得用于生物医学应用。
