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[放线菌产生的溶菌酶。II. 生物合成及实际应用领域]

[Bacteriolytic enzymes produced by actinomycetes. II. Biosynthesis and areas of practical application].

作者信息

Vinogradova K A, Kirillova N P, Polin A N

出版信息

Nauchnye Doki Vyss Shkoly Biol Nauki. 1989(2):5-16.

PMID:2659093
Abstract

The data on physiological conditions of the bacteriolytic enzyme formulation of actinomycetes, the population structure of producing cultures, the search of producers of enzymes able to hydrolyze the peptidoglycan of cellular walls of bacteria are reviewed. The fields of application of lytic enzymes in fundamental and applied microbiological investigations are pointed out. These enzymes are of considerable interest as potentially useful chemotherapeutics and food preservatives. They may be successfully used in biochemical and genetic investigation, in the study of peptidoglycan structure. The ability of bacteriolytic enzymes to cause the lysis of microorganisms resistant to the lysozyme action is of special importance. The application of these enzymes allows to work out gentle methods of lysis of bacterial cells used in various fields of microbiology.

摘要

综述了放线菌溶菌酶制剂的生理条件、生产培养物的种群结构以及能够水解细菌细胞壁肽聚糖的酶的生产者的研究数据。指出了溶菌酶在基础和应用微生物学研究中的应用领域。这些酶作为潜在有用的化学治疗剂和食品防腐剂具有相当大的研究价值。它们可成功用于生化和遗传学研究以及肽聚糖结构的研究。溶菌酶能够使对溶菌酶作用具有抗性的微生物发生裂解,这一点具有特别重要的意义。应用这些酶有助于开发出用于微生物学各个领域的温和的细菌细胞裂解方法。

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