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[放线菌产生的酶对A组链球菌细胞壁的溶解作用]

[Lysis of the cellular walls of Streptococcus group A by enzymes produced by actinomycetes].

作者信息

Savel'ev E P, Shmakova Z F, Petrov G I, Kuznetsov V D

出版信息

Antibiotiki. 1978 Oct;23(10):867-71.

PMID:360980
Abstract

More than 80 cultures of actinomycetes belonging to different taxanomic groups were studied with a purpose of screening actinomycetes actively producing enzymes lyzing the cell walls of group A streptococci. 31 strains of the actinomycetes producing enzymes which lyzed the cell walls by 20-50 and 60-80 per cent within 1 and 4 hours respectively were selected. The proteolytic activity of the enzymes produced by these strains was also studied. It was shown that 4 cultures, i.e. Actinomyces albus, strains 6 and 9, Actinomyces levoris, strain 29 and Actinomyces gibsonii, strain 42 were of interest as organisms producing enzymes which lyzed the streptococcal cell wall without impairing its antigenic components.

摘要

为筛选能积极产生裂解A组链球菌细胞壁的酶的放线菌,对80多种不同分类群的放线菌培养物进行了研究。挑选出了31株放线菌,它们所产生的酶分别在1小时和4小时内可使细胞壁裂解20%-50%和60%-80%。还研究了这些菌株所产生酶的蛋白水解活性。结果表明,有4种培养物值得关注,即白色放线菌6号和9号菌株、左旋放线菌29号菌株以及吉布森放线菌42号菌株,它们作为产生能裂解链球菌细胞壁而不损害其抗原成分的酶的微生物。

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