Herbeth B, Chavance M, Musse N, Mejean L, Vernhes G
Centre de Médecine Préventive, Vandoeuvre-les-Nancy, France.
Eur J Clin Nutr. 1989 Mar;43(3):175-86.
The relationships of diet, plasma lipids, age, gender, ponderal index, cigarette and alcohol consumption, drug use and infections to blood concentrations of retinol, beta-carotene, alpha-tocopherol, ascorbic acid and vitamins B1, B2, B6 status were studied among 291 men and women aged 60-82 years. Statistically significant correlations between dietary intake and blood indicator levels were found respectively for beta-carotene, alpha-tocopherol, ascorbic acid, vitamins B2 and B6, but not for retinol and thiamin, when the effects of other parameters were controlled. The main other determinants were cigarette consumption which had a negative effect on status for retinol, beta-carotene, alpha-tocopherol, ascorbic acid and vitamin B2; alcohol consumption for retinol, vitamin B6 (positive effect on status) and beta-carotene (decrease of plasma level); plasma lipids and use of hypolipaemic drugs for fat-soluble vitamins; ponderal index for beta-carotene and vitamin B6; gender and use of antibiotics for ascorbic acid. The apparent relation between gender and level of retinol, beta-carotene, alpha-tocopherol and vitamin B6 status was not any more significant after adjustment for alcohol or cigarette consumption. Tobacco and alcohol appear to be associated factors which should be controlled for in studies investigating relations between these vitamins and diseases influenced by smoking and drinking habits.
在291名年龄在60至82岁的男性和女性中，研究了饮食、血脂、年龄、性别、体重指数、吸烟和饮酒、药物使用及感染与血液中视黄醇、β-胡萝卜素、α-生育酚、抗坏血酸以及维生素B1、B2、B6水平之间的关系。在控制其他参数的影响后，分别发现饮食摄入量与血液指标水平之间在β-胡萝卜素、α-生育酚、抗坏血酸、维生素B2和B6方面存在统计学显著相关性，但视黄醇和硫胺素方面未发现。其他主要决定因素包括：吸烟对视黄醇、β-胡萝卜素、α-生育酚、抗坏血酸和维生素B2水平有负面影响；饮酒对视黄醇、维生素B6（对水平有正面影响）和β-胡萝卜素（血浆水平降低）有影响；血脂和使用降血脂药物对脂溶性维生素有影响；体重指数对β-胡萝卜素和维生素B6有影响；性别和使用抗生素对抗坏血酸有影响。在对饮酒或吸烟进行调整后，性别与视黄醇、β-胡萝卜素、α-生育酚和维生素B6水平之间的明显关系不再显著。烟草和酒精似乎是相关因素，在研究这些维生素与受吸烟和饮酒习惯影响的疾病之间的关系时应予以控制。
