Decaro Jason A, Manyama Mange, Wilson Warren
Department of Anthropology, The University of Alabama, Tuscaloosa, Alabama.
Department of Anatomy, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Am J Hum Biol. 2016 Jul;28(4):461-70. doi: 10.1002/ajhb.22807. Epub 2015 Nov 23.
Household conditions and culturally/socially variable childcare practices influence priming of the inflammatory response during infancy. Maternal mental health may partially mediate that effect. Among mother-infant dyads in Mwanza, Tanzania, we hypothesized that poorer maternal mental health would be associated with adverse household ecology, lower social capital, and greater inflammation among infants under the age of one; and that mental health would mediate any effects of household ecology/social capital on inflammation.
We collected dried blood spots from mother-infant dyads (N = 88) at health centers near Mwanza, Tanzania. To assess household ecology and social capital, we conducted interviews with mothers using the Household Food Insecurity Access Scale, the MacArthur Subjective Social Status Scale, and a household wealth inventory. We employed the Hopkins Symptom Checklist to assess maternal mental health. A high-sensitivity C-reactive protein (CRP) assay was used to quantify inflammation.
Severe food insecurity (OR: 5.16), lower subjective social status (r = -0.32), and lower household wealth (r = -0.26) were associated with high symptoms of maternal depression. Lower household wealth (r = -0.21) and severe food insecurity (OR: 2.52) were associated with high anxiety. High depression symptoms (OR: 2.56) and severe food insecurity (OR: 2.77) each were associated with greater-than-median infant CRP. However, mediation was not supported.
Maternal mental health should be considered alongside nutritional status, pathogen exposure, and education as a potential driver of very early innate immune system development. Proximal mechanisms warrant further investigation. Am. J. Hum. Biol. 28:461-470, 2016. © 2015 Wiley Periodicals, Inc.
家庭环境以及文化/社会层面多变的育儿方式会影响婴儿期炎症反应的启动。母亲的心理健康可能部分介导了这种影响。在坦桑尼亚姆万扎的母婴二元组中，我们假设母亲心理健康状况较差会与不良的家庭生态、较低的社会资本以及一岁以下婴儿更高的炎症水平相关；并且心理健康会介导家庭生态/社会资本对炎症的任何影响。
我们在坦桑尼亚姆万扎附近的健康中心收集了母婴二元组（N = 88）的干血斑。为了评估家庭生态和社会资本，我们使用家庭粮食不安全获取量表、麦克阿瑟主观社会地位量表和家庭财富清单对母亲进行访谈。我们采用霍普金斯症状清单来评估母亲的心理健康。使用高灵敏度C反应蛋白（CRP）检测来量化炎症。
严重的粮食不安全（比值比：5.16）、较低的主观社会地位（r = -0.32）和较低的家庭财富（r = -0.26）与母亲抑郁的高症状相关。较低的家庭财富（r = -0.21）和严重的粮食不安全（比值比：2.52）与高焦虑相关。高抑郁症状（比值比：2.56）和严重的粮食不安全（比值比：2.77）各自都与高于中位数的婴儿CRP相关。然而，中介作用未得到支持。
应将母亲的心理健康与营养状况、病原体暴露和教育一并视为极早期先天免疫系统发育的潜在驱动因素。近端机制值得进一步研究。《美国人类生物学杂志》28:461 - 470，2016年。© 2015威利期刊公司。
