Bender K I, Bobrova L A
Farmakol Toksikol. 1978 May-Jun;41(3):274-9.
Tests conducted on rabbits in a state of acute ethanol poisoning (2.5 g/kg per os) of a medium degree demonstrated that caffein (10 mg/kg) and bemegride (5 mg/kg) introduced one time intravenously at the height of alcoholic intoxication raise the activity of aerobic oxidative processes, but fail to eliminate metabolic acidosis and do not accelerate the excretion of ethanol. Unlike caffein, bemegride shows a tendency toward respiratory compensation of metabolic acidosis and lowers the activity of the alcohol-dehydrogenase.
在处于中度急性乙醇中毒（经口给予2.5克/千克）状态的兔子身上进行的试验表明，在酒精中毒高峰期一次性静脉注射咖啡因（10毫克/千克）和贝美格（5毫克/千克）可提高有氧氧化过程的活性，但无法消除代谢性酸中毒，也不能加速乙醇的排泄。与咖啡因不同，贝美格表现出对代谢性酸中毒进行呼吸代偿的趋势，并降低乙醇脱氢酶的活性。
