Zhou Xiaowei, Yu Youjun, Zhao Yuanxin, Wang Yuejian, Liu Zhen, Liu Qiuling
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 May;29(10):934-6.
To evaluate the efficacy of intratympanic dexamethasone injection for the moderate and severe sudden deafness with BPPV.
A total of 63 patients diagnosed with sudden sensorineural hearing loss with BPPV were treated through OPD. Patients were divided into three groups: 20 cases in intratympanic dexamethasone injection as initial treatment (group A); 18 cases in systemic hormone therapy group (group B); 25 cases in intratympanic dexamethasone injection as salvage treatment (group C). In addition, routine drugs were used to all patients.
The overall effective rate of group A, B and C in hearing recovery was 60.0%, 38.9% and 48.0%, respectively: (1) No significant difference of hearing recovery was observed among three groups (P > 0.05); (2) A significant difference of hearing recovery was evidenced between group A and C (P < 0.05); (3) A significant difference of hearing recovery was evidenced between group A and C (P < 0.05); (4) No statistically significant difference was found in the hearing recovery between group B and C (P > 0.05).
Our data showed that intratympanic dexamethasone should be used as initial therapy for treating the moderate and severe sudden deafness with BPPV.
评估鼓室内注射地塞米松治疗中度和重度突发性聋伴良性阵发性位置性眩晕（BPPV）的疗效。
总共63例被诊断为突发性聋伴BPPV的患者在门诊接受治疗。患者被分为三组：20例以鼓室内注射地塞米松作为初始治疗（A组）；18例为全身激素治疗组（B组）；25例以鼓室内注射地塞米松作为挽救治疗（C组）。此外，所有患者均使用常规药物。
A、B、C三组听力恢复的总有效率分别为60.0%、38.9%和48.0%：（1）三组之间听力恢复情况无显著差异（P>0.05）；（2）A组和C组之间听力恢复有显著差异（P<0.05）；（3）A组和C组之间听力恢复有显著差异（P<0.05）；（4）B组和C组之间听力恢复无统计学显著差异（P>0.05）。
我们的数据表明，鼓室内注射地塞米松应用作治疗中度和重度突发性聋伴BPPV的初始治疗方法。
