Lenz T, Sealey J E, August P, James G D, Laragh J H
Cardiovascular Center, New York Hospital-Cornell University Medical College, New York 10021.
J Clin Endocrinol Metab. 1989 Jul;69(1):31-7. doi: 10.1210/jcem-69-1-31.
The components of the renin system are present in placental tissue, but their function in this tissue is not known. We investigated the relative distribution of the various components throughout the placenta to determine whether the distribution is consistent with a role for them in parturition or in stimulation or inhibition of placental hormone biosynthesis. Thus, active and total renin were measured in fetal membranes (chorion laeve and amnion) and in discoid placenta (chorion frondosum and chorion plate) of women who were delivered vaginally (n = 12) or by cesarean section with (n = 6) or without labor (n = 9). The interrelationships between active and total renin and angiotensinogen, progesterone, hCG, and estradiol concentrations were investigated. Labor had no significant effect on the concentration of active or total renin, angiotensinogen, hCG, or estradiol in any part of the placenta. Tissue progesterone concentrations were higher in placentas from women who underwent vaginal deliveries than in those who had cesarean sections with or without labor (P less than 0.02). The chorion laeve had 20 times more total renin per g than the discoid placenta and 3 times more than the amnion. In contrast the discoid placenta had 5 times more hCG per g and 3 times more progesterone per g than the fetal membranes. The concentration of estradiol was lower in amnion, while that of angiotensinogen was lower in the chorion frondosum than in all other regions. The tissue concentrations of active renin, prorenin, or total renin were not related to those of any of the other hormones. Altogether these data do not provide evidence of a role for the placental renin system in parturition or placental hormone biosynthesis.
肾素系统的成分存在于胎盘组织中，但其在该组织中的功能尚不清楚。我们研究了各种成分在整个胎盘中的相对分布，以确定这种分布是否与它们在分娩、刺激或抑制胎盘激素生物合成中的作用相一致。因此，我们测量了经阴道分娩的女性（n = 12）、剖宫产且有（n = 6）或无分娩（n = 9）的女性的胎膜（平滑绒毛膜和羊膜）以及盘状胎盘（叶状绒毛膜和绒毛板）中的活性肾素和总肾素。研究了活性肾素、总肾素与血管紧张素原、孕酮、人绒毛膜促性腺激素（hCG）和雌二醇浓度之间的相互关系。分娩对胎盘任何部位的活性或总肾素、血管紧张素原、hCG或雌二醇浓度均无显著影响。经阴道分娩的女性胎盘组织中的孕酮浓度高于剖宫产且有或无分娩的女性胎盘组织中的孕酮浓度（P < 0.02）。每克平滑绒毛膜中的总肾素含量比盘状胎盘多20倍，比羊膜多3倍。相比之下，每克盘状胎盘的hCG含量比胎膜多5倍，孕酮含量多3倍。羊膜中的雌二醇浓度较低，而叶状绒毛膜中的血管紧张素原浓度低于所有其他区域。活性肾素、肾素原或总肾素的组织浓度与其他任何激素的浓度均无关联。总体而言，这些数据并未提供胎盘肾素系统在分娩或胎盘激素生物合成中起作用的证据。
