Lerner College of Medicine, Cleveland Clinic, Cleveland, Ohio.
Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio.
J Urol. 2016 Apr;195(4 Pt 1):987-91. doi: 10.1016/j.juro.2015.11.026. Epub 2015 Nov 17.
Although the 2007 AUA (American Urological Association) guidelines established it as first line therapy for ureteral stones less than 10 mm, widespread adoption of medical expulsive therapy has been low. We determined the current penetrance of medical expulsive therapy guideline recommendations and the efficacy of medical expulsive therapy in reducing the requirement for urological procedures after emergency department visits for ureteral stones.
In a retrospective analysis of patients seen in the emergency department we included 2,105 emergency department visits associated with an ICD-9 diagnosis of urolithiasis in which computerized tomography abdomen/pelvis scan was performed. Outcomes were reviewed for spontaneous passage or required urological procedure.
Ureteral stones were found in 48.8% of patients, including 50.0% in whom medical expulsive therapy was prescribed. There was no significant difference between patients who did and did not receive medical expulsive therapy. Within 12 weeks of the initial emergency department visit there was no difference in the rate of urological procedures performed in those who received medical expulsive therapy or in the rate of return to the emergency department. Patients treated with medical expulsive therapy experienced a shorter time to spontaneous expulsion (7.1 vs 12.8 days, p = 0.048).
Medical expulsive therapy for renal colic in the emergency setting remains underused. Half of the patients who met criteria for medical expulsive therapy in this study did not receive the standard of care. Patients treated with medical expulsive therapy achieved spontaneous passage more quickly but there was no difference in the requirement for a urological procedure. These results highlight the need for personnel at emergency departments to better standardize care for patients with ureteral stones.
尽管 2007 年美国泌尿外科学会(AUA)指南将其确立为治疗小于 10mm 的输尿管结石的一线治疗方法,但医疗排石疗法的广泛应用率一直较低。我们确定了目前医疗排石疗法指南建议的接受程度,以及医疗排石疗法在减少因输尿管结石就诊急诊科后需要泌尿科手术的疗效。
在对急诊科就诊患者的回顾性分析中,我们纳入了 2105 例因 ICD-9 诊断为尿石症而行腹部/骨盆 CT 扫描的急诊科就诊患者。对自发性排石或需要泌尿科手术的情况进行了结果回顾。
48.8%的患者发现输尿管结石,其中 50.0%的患者接受了医疗排石疗法。接受和未接受医疗排石疗法的患者之间没有显著差异。在首次急诊科就诊后的 12 周内,接受和未接受医疗排石疗法的患者行泌尿科手术的比例没有差异,也没有差异返回急诊科的比例。接受医疗排石疗法的患者自发性排石的时间更短(7.1 天 vs 12.8 天,p = 0.048)。
在急诊科治疗肾绞痛时,医疗排石疗法仍未得到充分应用。本研究中符合医疗排石疗法标准的患者中有一半未接受标准治疗。接受医疗排石疗法的患者更快地实现了自发性排石,但在需要泌尿科手术的方面没有差异。这些结果强调了急诊科人员需要更好地规范输尿管结石患者的治疗。