呼气力量训练对肌萎缩侧索硬化症的影响。
Impact of expiratory strength training in amyotrophic lateral sclerosis.
作者信息
Plowman Emily K, Watts Stephanie A, Tabor Lauren, Robison Raele, Gaziano Joy, Domer Amanda S, Richter Joel, Vu Tuan, Gooch Clifton
机构信息
Department of Speech, Language and Hearing Sciences, University of Florida, P.O. Box 117420, Gainesville, Florida, 32610, USA.
Neuromotor Speech and Swallowing Restoration Laboratory, University of Florida, Gainesville, Florida, USA.
出版信息
Muscle Nerve. 2016 Jun;54(1):48-53. doi: 10.1002/mus.24990. Epub 2016 Mar 3.
INTRODUCTION
We evaluated the feasibility and impact of expiratory muscle strength training (EMST) on respiratory and bulbar function in persons with amyotrophic lateral sclerosis (ALS).
METHODS
Twenty-five ALS patients participated in this delayed intervention open-label clinical trial. Following a lead-in period, patients completed a 5-week EMST protocol. Outcome measures included: maximum expiratory pressure (MEP); physiologic measures of swallow and cough; and penetration-aspiration scale (PAS) scores.
RESULTS
Of participants who entered the active phase of the study (n = 15), EMST was well tolerated and led to significant increases in MEPs and maximum hyoid displacement during swallowing post-EMST (P < 0.05). No significant differences were observed for PAS scores or cough spirometry measures.
CONCLUSIONS
EMST was feasible and well tolerated in this small cohort of ALS patients and led to improvements in expiratory force-generating pressures and swallow kinematics. Further investigation is warranted to confirm these preliminary findings. Muscle Nerve 54: 48-53, 2016.
引言
我们评估了呼气肌力量训练（EMST）对肌萎缩侧索硬化症（ALS）患者呼吸和延髓功能的可行性及影响。
方法
25名ALS患者参与了这项延迟干预开放标签临床试验。在导入期后，患者完成了为期5周的EMST方案。结果指标包括：最大呼气压力（MEP）；吞咽和咳嗽的生理指标；以及渗透-误吸量表（PAS）评分。
结果
进入研究活跃期的参与者（n = 15）中，EMST耐受性良好，且导致EMST后吞咽时MEP和舌骨最大位移显著增加（P < 0.05）。PAS评分或咳嗽肺量计测量未观察到显著差异。
结论
在这个小样本ALS患者队列中，EMST是可行的且耐受性良好，并导致呼气产生压力和吞咽运动学方面的改善。有必要进行进一步研究以证实这些初步发现。《肌肉与神经》54: 48 - 53, 2016年。
Zotero 插件