Swallowing Systems Core, University of Florida, Gainesville, Florida, USA.
Department of Speech, Language and Hearing Sciences, College of Public Health and Health Professions, University of Florida, P.O. Box 117420, Gainesville, Florida, 32610, USA.
Muscle Nerve. 2019 Jan;59(1):40-46. doi: 10.1002/mus.26292. Epub 2018 Nov 29.
INTRODUCTION: The purpose of this study was to determine the impact of an in-home expiratory muscle strength training (EMST) program on pulmonary, swallow, and cough function in individuals with amyotrophic lateral sclerosis (ALS). METHODS: EMST was tested in a prospective, single-center, double-blind, randomized, controlled trial of 48 ALS individuals who completed 8 weeks of either active EMST (n = 24) or sham EMST (n = 24). The primary outcome to assess treatment efficacy was change in maximum expiratory pressure (MEP). Secondary outcomes included: cough spirometry; swallowing; forced vital capacity; and scoring on the ALS Functional Rating Scale-Revised. RESULTS: Treatment was well tolerated with 96% of patients completing the protocol. Significant differences in group change scores were noted for MEP and Dynamic Imaging Grade of Swallowing Toxicity scores (P < 0.02). No differences were noted for other secondary measures. DISCUSSION: This respiratory training program was well-tolerated and led to improvements in respiratory and bulbar function in ALS. Muscle Nerve 59:40-46, 2019.
简介：本研究旨在确定家庭呼气肌力量训练（EMST）方案对肌萎缩侧索硬化症（ALS）患者的肺、吞咽和咳嗽功能的影响。
方法：在一项前瞻性、单中心、双盲、随机、对照试验中对 48 名 ALS 患者进行了 EMST 测试，这些患者完成了 8 周的主动 EMST（n=24）或假 EMST（n=24）。评估治疗效果的主要结果是最大呼气压力（MEP）的变化。次要结果包括：咳嗽肺活量测定法；吞咽；用力肺活量；以及 ALS 功能评定量表修订版的评分。
结果：治疗耐受良好，96%的患者完成了方案。MEP 和动态成像吞咽毒性评分的组间变化评分差异显著（P<0.02）。其他次要措施无差异。
讨论：该呼吸训练方案耐受性良好，可改善 ALS 患者的呼吸和延髓功能。肌肉神经 59：40-46，2019。
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