牛诺如病毒突出结构域的结构分析
Structural analysis of bovine norovirus protruding domain.
作者信息
Singh Bishal Kumar, Koromyslova Anna, Hansman Grant S
机构信息
Schaller Research Group at the University of Heidelberg and the DKFZ, Heidelberg 69120, Germany; Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg 69120, Germany.
Schaller Research Group at the University of Heidelberg and the DKFZ, Heidelberg 69120, Germany; Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg 69120, Germany.
出版信息
Virology. 2016 Jan;487:296-301. doi: 10.1016/j.virol.2015.10.022. Epub 2015 Nov 18.
We determined a structure of a bovine (genogroup III, GIII) norovirus capsid protruding (P) domain using X-ray crystallography. The bovine P domain was reminiscent of other norovirus genogroups (GI, GII, GIV, and GV), but closely matched the human GI P domain. We also identified a monoclonal antibody that was capable of binding the five different (GI-GV) P domains. Our data suggests that genetically diverse noroviruses still contain common epitopes.
我们利用X射线晶体学确定了牛（基因组III型，GIII）诺如病毒衣壳突出（P）结构域的结构。牛P结构域让人联想到其他诺如病毒基因组（GI、GII、GIV和GV），但与人类GI P结构域紧密匹配。我们还鉴定出一种能够结合五种不同（GI - GV）P结构域的单克隆抗体。我们的数据表明，基因多样的诺如病毒仍含有共同表位。
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