2014 - 2015年新出现的GII.17诺如病毒的结构演变
Structural Evolution of the Emerging 2014-2015 GII.17 Noroviruses.
作者信息
Singh Bishal Kumar, Koromyslova Anna, Hefele Lisa, Gürth Clara, Hansman Grant S
机构信息
Schaller Research Group, University of Heidelberg and DKFZ, Heidelberg, Germany Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany.
Schaller Research Group, University of Heidelberg and DKFZ, Heidelberg, Germany Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany
出版信息
J Virol. 2015 Dec 23;90(5):2710-5. doi: 10.1128/JVI.03119-15.
Abstract
Recent reports suggest that human genogroup II genotype 17 (GII.17) noroviruses are increasing in prevalence. We analyzed the evolutionary changes of three GII.17 capsid protruding (P) domains. We found that the GII.17 P domains had little cross-reactivity with antisera raised against the dominant GII.4 strains. X-ray structural analysis of GII.17 P domains from 2002 to 2014 and 2015 suggested that surface-exposed substitutions on the uppermost part of the P domain might have generated a novel 2014-2015 GII.17 variant.
摘要
近期报告表明，人类基因组II型基因型17（GII.17）诺如病毒的流行率正在上升。我们分析了三种GII.17衣壳突出（P）结构域的进化变化。我们发现，GII.17 P结构域与针对主要GII.4毒株产生的抗血清几乎没有交叉反应性。对2002年至2014年以及2015年的GII.17 P结构域进行的X射线结构分析表明，P结构域最上部表面暴露的替换可能产生了一种新的2014 - 2015年GII.17变体。
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