Yin W, Bian Z
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
Department of Endodontics & Periodontics, College of Stomatology, Dalian Medical University, Dalian, China.
Oral Dis. 2016 May;22(4):265-73. doi: 10.1111/odi.12400. Epub 2016 Jan 13.
Tooth agenesis and tumor are two totally different diseases occurring at different ages. In the past 10 years, more and more evidences suggested there was a relationship between them. High prevalence of breast, colon, lung, and ovary tumor was observed in tooth agenesis patients. But it is still controversial. Therefore, to have a greater understanding of the possible association, a critical review on molecular association for genes involving tooth agenesis and tumorigenesis is necessary. In this current review, we summarized the reported cases of tooth agenesis with different kinds of tumors and the molecular relationship between these two diseases through causative genes. The results indicated tooth agenesis might be a prospective predictive marker for tumor. Through this review, we want to draw more attention on this topic and hope it will be an effective way to predict the risk of tumor.
牙齿发育不全和肿瘤是两种发生在不同年龄段的完全不同的疾病。在过去十年中，越来越多的证据表明它们之间存在关联。在牙齿发育不全患者中观察到乳腺癌、结肠癌、肺癌和卵巢癌的高发病率。但这仍存在争议。因此，为了更深入了解可能的关联，有必要对涉及牙齿发育不全和肿瘤发生的基因的分子关联进行批判性综述。在本综述中，我们通过致病基因总结了报道的牙齿发育不全合并不同类型肿瘤的病例以及这两种疾病之间的分子关系。结果表明牙齿发育不全可能是肿瘤的一个前瞻性预测标志物。通过本综述，我们希望引起对该主题更多的关注，并希望它将成为预测肿瘤风险的有效方法。
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