实验性甲状腺毒症对脑灰质的影响：一项基于体素的形态测量学研究。
Effect of Experimental Thyrotoxicosis on Brain Gray Matter: A Voxel-Based Morphometry Study.
作者信息
Göbel Anna, Heldmann Marcus, Göttlich Martin, Dirk Anna-Luise, Brabant Georg, Münte Thomas F
机构信息
Department of Neurology, University of Lübeck, Lübeck, Germany.
Department of Internal Medicine I, University of Lübeck, Lübeck, Germany.
出版信息
Eur Thyroid J. 2015 Sep;4(Suppl 1):113-8. doi: 10.1159/000398793. Epub 2015 May 30.
Abstract
BACKGROUND
Hyper-as well hypothyroidism have an effect on behavior and brain function. Moreover, during development thyroid hormones influence brain structure.
OBJECTIVES
This study aimed to demonstrate an effect of experimentally induced hyperthyroidism on brain gray matter in healthy adult humans.
METHODS
High-resolution 3D T1-weighted images were acquired in 29 healthy young subjects prior to as well as after receiving 250 µg of T4 per day for 8 weeks. Voxel-based morphometry analysis was performed using Statistical Parametric Mapping 8 (SPM8).
RESULTS
Laboratory testing confirmed the induction of hyperthyroidism. In the hyperthyroid condition, gray matter volumes were increased in the right posterior cerebellum (lobule VI) and decreased in the bilateral visual cortex and anterior cerebellum (lobules I-IV) compared to the euthyroid condition.
CONCLUSIONS
Our study provides evidence that short periods of hyperthyroidism induce distinct alterations in brain structures of cerebellar regions that have been associated with sensorimotor functions as well as working memory in the literature.
摘要
背景
甲状腺功能亢进以及甲状腺功能减退都会影响行为和脑功能。此外，在发育过程中甲状腺激素会影响脑结构。
目的
本研究旨在证明实验性诱导的甲状腺功能亢进对健康成年人类脑灰质的影响。
方法
对29名健康年轻受试者在每天接受250μg T4治疗8周之前和之后采集高分辨率3D T1加权图像。使用统计参数映射8（SPM8）进行基于体素的形态学分析。
结果
实验室检测证实了甲状腺功能亢进的诱导。与甲状腺功能正常状态相比，在甲状腺功能亢进状态下，右侧小脑后部（小叶VI）的灰质体积增加，双侧视觉皮层和小脑前部（小叶I-IV）的灰质体积减少。
结论
我们的研究提供了证据表明，短期甲状腺功能亢进会在小脑区域的脑结构中引起明显改变，这些区域在文献中与感觉运动功能以及工作记忆相关。
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