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由于THRB基因突变导致甲状腺激素抵抗的受试者大脑结构的变化。

Changes in brain structure in subjects with resistance to thyroid hormone due to THRB mutations.

作者信息

Rogge Berenike, Heldmann Marcus, Chatterjee Krishna, Moran Carla, Göttlich Martin, Uter Jan, Wagner-Altendorf Tobias A, Steinhardt Julia, Brabant Georg, Münte Thomas F, Cirkel Anna

机构信息

Department of Neurology, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany.

Department of Psychology II, University of Lübeck, Lübeck, Germany.

出版信息

Thyroid Res. 2023 Nov 6;16(1):34. doi: 10.1186/s13044-023-00176-2.

DOI:10.1186/s13044-023-00176-2
PMID:37592301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10433577/
Abstract

BACKGROUND

Being critical for brain development and neurocognitive function thyroid hormones may have an effect on behaviour and brain structure. Our exploratory study aimed to delineate the influence of mutations in the thyroid hormone receptor (TR) ß gene on brain structure.

METHODS

High-resolution 3D T1-weighted images were acquired in 21 patients with a resistance to thyroid hormone ß (RTHß) in comparison to 21 healthy matched-controls. Changes in grey and white matter, as well as cortical thickness were evaluated using voxel-based morphometry (VBM) and diffusion tensor imaging (DTI).

RESULTS

RTHß patients showed elevated circulating fT4 & fT3 with normal TSH concentrations, whereas controls showed normal thyroid hormone levels. RTHß patients revealed significantly higher scores in a self-rating questionnaire for attention deficit hyperactivity disorder (ADHD). Imaging revealed alterations of the corticospinal tract, increased cortical thickness in bilateral superior parietal cortex and decreased grey matter volume in bilateral inferior temporal cortex and thalamus.

CONCLUSION

RTHb patients exhibited structural changes in multiple brain areas. Whether these structural changes are causally linked to the abnormal behavioral profile of RTHß which is similar to ADHD, remains to be determined.

摘要

背景

甲状腺激素对大脑发育和神经认知功能至关重要，可能会对行为和脑结构产生影响。我们的探索性研究旨在阐明甲状腺激素受体（TR）β基因中的突变对脑结构的影响。

方法

对21例甲状腺激素β抵抗（RTHβ）患者和21例健康匹配对照者进行了高分辨率3D T1加权成像。使用基于体素的形态学测量（VBM）和扩散张量成像（DTI）评估灰质和白质的变化以及皮质厚度。

结果

RTHβ患者的循环游离T4和游离T3升高，促甲状腺激素（TSH）浓度正常，而对照组甲状腺激素水平正常。RTHβ患者在注意力缺陷多动障碍（ADHD）自评问卷中的得分显著更高。影像学检查发现皮质脊髓束改变，双侧顶上叶皮质厚度增加，双侧颞下回皮质和丘脑灰质体积减少。

结论

RTHβ患者在多个脑区出现结构变化。这些结构变化是否与RTHβ类似于ADHD的异常行为特征存在因果关系，仍有待确定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/057b/10433577/fe3672b2385e/13044_2023_176_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/057b/10433577/687550d0da1c/13044_2023_176_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/057b/10433577/7f30bd53a486/13044_2023_176_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/057b/10433577/2938902e2987/13044_2023_176_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/057b/10433577/fe3672b2385e/13044_2023_176_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/057b/10433577/687550d0da1c/13044_2023_176_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/057b/10433577/7f30bd53a486/13044_2023_176_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/057b/10433577/2938902e2987/13044_2023_176_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/057b/10433577/fe3672b2385e/13044_2023_176_Fig4_HTML.jpg

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