Lee Robert J, Tong Elizabeth L, Patel Riki, Satyadev Nihal, Christensen Russell E
Dental Student, UCLA School of Dentistry, Los Angeles, CA, USA.
Master's Student, Department of Statistics, UCLA, Los Angeles, CA, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Feb;121(2):180-7. doi: 10.1016/j.oooo.2015.09.019. Epub 2015 Oct 13.
To determine the demographic characteristics, prognostic factors, and optimal treatment modalities of patients diagnosed with malignant primary tumors of the sublingual gland.
The Surveillance, Epidemiology, and End Results (SEER) registry contains 210 patients diagnosed with sublingual gland tumors in the SEER database. Kaplan-Meier and multivariate Cox regression analysis were performed on age, sex, race, histologic subtype, stage, and treatment modality.
Kaplan-Meier analysis found an overall survival and disease-specific survival at 5 years of 69% and 83%, respectively. Multivariate analysis demonstrated that age, sex, stage, and surgery were predictors of overall survival, whereas stage was a predictor of disease-specific survival.
Here we report, to our knowledge, the largest study to date investigating demographic characteristics, prognostic factors, and treatment modalities of patients diagnosed with primary malignant tumors of the sublingual gland. Increased age and stage correlated with decreased survival, whereas female gender and surgical therapy correlated with increased survival in the overall population. Radiation therapy for patients diagnosed with adenoid cystic carcinoma in the sublingual gland was correlated with increased survival.
确定诊断为舌下腺原发性恶性肿瘤患者的人口统计学特征、预后因素及最佳治疗方式。
监测、流行病学和最终结果（SEER）登记处包含SEER数据库中210例诊断为舌下腺肿瘤的患者。对年龄、性别、种族、组织学亚型、分期和治疗方式进行了Kaplan-Meier分析和多变量Cox回归分析。
Kaplan-Meier分析发现5年总生存率和疾病特异性生存率分别为69%和83%。多变量分析表明，年龄、性别、分期和手术是总生存的预测因素，而分期是疾病特异性生存的预测因素。
据我们所知，在此我们报告了迄今为止关于诊断为舌下腺原发性恶性肿瘤患者的人口统计学特征、预后因素及治疗方式的最大规模研究。年龄增加和分期增加与生存率降低相关，而女性性别和手术治疗与总体人群生存率增加相关。舌下腺腺样囊性癌患者接受放射治疗与生存率增加相关。
