Lee Robert J, Tong Elizabeth L, Patel Riki, Go Leslie A, Christensen Russell E
Dental Student, UCLA School of Dentistry, Los Angeles, California, USA.
Master's Student, Department of Statistics, UCLA, Los Angeles, California, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Nov;120(5):616-21. doi: 10.1016/j.oooo.2015.07.015. Epub 2015 Jul 23.
To determine the demographic characteristics, prognostic factors, and management for patients diagnosed with a malignant odontogenic tumor (MOT).
The Surveillance, Epidemiology, and End Results (SEER) registry was reviewed for patients diagnosed with MOT from 1973 to 2011. Kaplan-Meier and multivariate Cox regression analyses were performed on patient demographic characteristics and pathologic variables.
The SEER database identified 295 MOT patients. The mean age at diagnosis was 50.5 years (range 5-89 years). Of these patients, 61.7% were male and 38.3% were female. The racial composition was 66.4% White, 22% Black, 6.1% Asian, 3.1% Pacific Islander, 0.3% Native American, and 2.1% Other/Unknown. Kaplan-Meier analysis found an overall survival (OS) and disease-specific survival (DSS) at 5 years of 54% and 67%, respectively. Multivariate analysis of the entire cohort found that age and stage were predictors of OS and that age was a predictor for DSS. For stage I/II MOTs, age and surgical therapy were predictors of OS and DSS, respectively.
Here we report the largest study to date investigating demographic characteristics, prognostic factors, and management of MOT patients. Determinants of survival for OS and DSS include age, stage, and surgical therapy.
确定诊断为恶性牙源性肿瘤（MOT）患者的人口统计学特征、预后因素及治疗方法。
回顾监测、流行病学及最终结果（SEER）登记处1973年至2011年诊断为MOT的患者。对患者人口统计学特征和病理变量进行Kaplan-Meier和多变量Cox回归分析。
SEER数据库识别出295例MOT患者。诊断时的平均年龄为50.5岁（范围5 - 89岁）。这些患者中，61.7%为男性，38.3%为女性。种族构成是66.4%为白人，22%为黑人，6.1%为亚洲人，3.1%为太平洋岛民，0.3%为美洲原住民，2.1%为其他/不明。Kaplan-Meier分析发现5年总生存率（OS）和疾病特异性生存率（DSS）分别为54%和67%。对整个队列的多变量分析发现年龄和分期是OS的预测因素，年龄是DSS的预测因素。对于I/II期MOT，年龄和手术治疗分别是OS和DSS的预测因素。
我们在此报告了迄今为止关于MOT患者人口统计学特征、预后因素及治疗方法的最大规模研究。OS和DSS生存的决定因素包括年龄、分期和手术治疗。
