Goh Amanda Yl, Layton Christopher J
School of Medicine, University of Queensland, Brisbane, Queensland, Australia.
Gallipoli Medical Research Institute, Brisbane, Queensland, Australia.
Clin Exp Ophthalmol. 2016 Aug;44(6):509-19. doi: 10.1111/ceo.12688. Epub 2016 Feb 11.
Uveal melanoma (UM) is the most common primary ocular tumour in adults. Despite good local control of the primary tumour with current methods, survival after the development of metastasis has remained poor over the last 30 years. After cutaneous melanoma, UM is the most common type of melanoma, and an ongoing debate exists regarding whether these conditions should be considered separate entities, particularly in the context of targeted therapy, where many of the initial trials for patients with metatatic cutaneous melanoma excluded metastatic UM. This paper will review the recent and ongoing investigations designed to validate systemic targeted therapy and immunotherapy in patients with metastatic UM and suggests ways in which these developments may affect management of UM by ophthalmologists in the near future.
葡萄膜黑色素瘤（UM）是成人中最常见的原发性眼部肿瘤。尽管目前的方法对原发性肿瘤有良好的局部控制，但在过去30年中，发生转移后的生存率仍然很低。除皮肤黑色素瘤外，UM是黑色素瘤最常见的类型，关于这些情况是否应被视为独立的实体存在持续的争论，特别是在靶向治疗的背景下，许多针对转移性皮肤黑色素瘤患者的初始试验排除了转移性UM。本文将回顾近期及正在进行的旨在验证转移性UM患者的全身靶向治疗和免疫治疗的研究，并提出这些进展在不久的将来可能影响眼科医生对UM治疗的方式。
