脑弓形虫病患者脑脊液样本中弓形虫特异性IgG亚类抗体反应
Toxoplasma-SPECIFIC IgG SUBCLASS ANTIBODY RESPONSE IN CEREBROSPINAL FLUID SAMPLES FROM PATIENTS WITH CEREBRAL TOXOPLASMOSIS.
作者信息
Nascimento Fernanda S, Suzuki Lisandra A, Branco Nilson, Franco Regina M B, Andrade Paula D, Costa Sandra C B, Pedro Marcelo N, Rossi Cláudio L
机构信息
Departamento de Patologia Clínica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brasil.
Departamento de Biologia Animal, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brasil.
出版信息
Rev Inst Med Trop Sao Paulo. 2015 Sep-Oct;57(5):439-42. doi: 10.1590/S0036-46652015000500013.
Cerebral toxoplasmosis can be highly debilitating and occasionally fatal in persons with immune system deficiencies. In this study, we evaluated the Toxoplasma gondii-specific IgG subclass antibody response in 19 cerebrospinal fluid (CSF) samples from patients with cerebral toxoplasmosis who had a positive IgG anti-T. gondii ELISA standardized with a cyst antigen preparation. There were no significant differences between the rates of positivity and the antibody concentrations (arithmetic means of the ELISA absorbances, MEA) for IgG1 and IgG2, but the rates of positivity and MEA values for these two IgG subclasses were significantly higher than those for IgG3 and IgG4. The marked IgG2 response in CSF from patients with cerebral toxoplasmosis merits further investigation.
脑弓形虫病在免疫系统有缺陷的人群中可能会导致严重身体衰弱，偶尔还会致命。在本研究中，我们评估了19份来自脑弓形虫病患者的脑脊液（CSF）样本中的弓形虫特异性IgG亚类抗体反应，这些患者的抗弓形虫IgG ELISA检测呈阳性，该检测采用包囊抗原制剂进行标准化。IgG1和IgG2的阳性率和抗体浓度（ELISA吸光度的算术平均值，MEA）之间没有显著差异，但这两个IgG亚类的阳性率和MEA值显著高于IgG3和IgG4。脑弓形虫病患者脑脊液中显著的IgG2反应值得进一步研究。
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