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先天性弓形虫病：母婴配对中的特异性IgG亚类

Congenital toxoplasmosis: specific IgG subclasses in mother/newborn pairs.

作者信息

Cañedo-Solares Irma, Galván-Ramírez María de la Luz, Luna-Pastén Héctor, Rodríguez Pérez Laura Rocío, Ortiz-Alegría Luz Belinda, Rico-Torres Claudia Patricia, Vela-Amieva Marcela, Pérez-Andrade Martha, Figueroa-Damián Ricardo, Correa Dolores

机构信息

Inmunología Experimental, Subdirección de Medicina Experimental, Instituto Nacional de Pediatría, Secretaría de Salud, México DF.

出版信息

Pediatr Infect Dis J. 2008 May;27(5):469-74. doi: 10.1097/INF.0b013e31816591df.

DOI:10.1097/INF.0b013e31816591df
PMID:18520342
Abstract

Anti-Toxoplasma gondii antibodies of all IgG subclasses were studied in mother/newborn pairs. IgG1 in the mothers and IgG3 in the newborns were related to offspring clinical problems; IgG2 and IgG3 in the babies were markers of vertical transmission, and IgG4 in mothers or children were associated to clinical problems. IgG subclasses may be markers of congenital infection or clinical outcome.

摘要

在母婴配对中研究了所有IgG亚类的抗弓形虫抗体。母亲体内的IgG1和新生儿体内的IgG3与后代临床问题有关；婴儿体内的IgG2和IgG3是垂直传播的标志物，母亲或儿童体内的IgG4与临床问题相关。IgG亚类可能是先天性感染或临床结局的标志物。

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