Department of Psychiatry, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.
Laboratory of Genetics, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, San Diego, CA 92037, USA.
Stem Cell Reports. 2015 Dec 8;5(6):933-945. doi: 10.1016/j.stemcr.2015.10.011. Epub 2015 Nov 21.
As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field.
我们聚集在一起讨论了目前在创建有意义的用于研究脑疾病的患者特异性体外模型方面所面临的挑战。虽然实验室和患者队列的研究结果趋同，使我们有信心和乐观地认为基于 hiPSC 的平台将为未来的药物发现工作提供信息，但仍存在许多关键技术挑战。本文概述了我们对基于 hiPSC 的疾病建模现状的集体看法，并讨论了我们认为作为一个领域必须共同解决的关键目标。
