Lima Guilherme Lucas de Oliveira, Zanello Marc, Mandonnet Emmanuel, Taillandier Luc, Pallud Johan, Duffau Hugues
Department of Neurosurgery, Onofre Lopes University Hospital, Rio Grande do Norte Federal University, Natal, RN, Brazil.
Department of Neurosurgery, Sainte-Anne Hospital, Paris, France.
Neurosurg Rev. 2016 Jul;39(3):377-84. doi: 10.1007/s10143-015-0675-6. Epub 2015 Nov 27.
Although a large amount of data supports early surgical resection for symptomatic diffuse low-grade glioma, the therapeutic strategy is still a matter of debate regarding incidentally discovered diffuse low-grade glioma. Indeed, early and "preventive" surgery has recently been proposed in asymptomatic patients with silent diffuse low-grade glioma with better outcomes. The present review discusses the importance of an early diagnosis and of a preventive surgical treatment to improve the outcomes of incidental diffuse low-grade glioma and suggests the possible relevance of a tailored screening policy.
尽管大量数据支持对有症状的弥漫性低级别胶质瘤进行早期手术切除，但对于偶然发现的弥漫性低级别胶质瘤，其治疗策略仍存在争议。事实上，最近有人提出对无症状的静止性弥漫性低级别胶质瘤患者进行早期“预防性”手术，结果更好。本综述讨论了早期诊断和预防性手术治疗对改善偶然发现的弥漫性低级别胶质瘤预后的重要性，并提出了定制筛查策略的可能相关性。
