Noorani Imran, Sanai Nader
Department of Neurological Surgery, Barrow Neurological Institute, Saint Joseph's Hospital and Medical Center, 350 W Thomas Rd, Phoenix, AZ 85013, USA; Department of Neurosurgery, Addenbrooke's Hospital, Hills Rd, Cambridge CB2 0QQ, UK.
Department of Neurological Surgery, Barrow Neurological Institute, Saint Joseph's Hospital and Medical Center, 350 W Thomas Rd, Phoenix, AZ 85013, USA.
Neurosurg Clin N Am. 2017 Jul;28(3):397-406. doi: 10.1016/j.nec.2017.02.008.
Detailed brain imaging studies discover gliomas incidentally before clinical symptoms or signs show. These tumors represent an early stage in the natural history of gliomas. Left untreated, they are likely to progress to a symptomatic stage and transform to malignant gliomas. A greater extent of resection delays the onset of malignant transformation and prolongs patient survival. Because incidental gliomas are typically smaller and less likely to be in eloquent brain locations, there is a strong case for early surgical intervention to maximize resection and improve outcomes. This article discusses developments in the surgical management of low-grade gliomas.
详细的脑成像研究在临床症状或体征出现之前偶然发现了胶质瘤。这些肿瘤代表了胶质瘤自然病程的早期阶段。如果不进行治疗，它们很可能进展到有症状阶段并转变为恶性胶质瘤。更大范围的切除可延迟恶性转化的发生并延长患者生存期。由于偶然发现的胶质瘤通常较小且不太可能位于脑功能区，因此有充分理由进行早期手术干预，以最大限度地切除肿瘤并改善预后。本文讨论了低级别胶质瘤外科治疗的进展。
