前列腺癌的分子进展

Molecular Updates in Prostate Cancer.

作者信息

Netto George J

机构信息

Johns Hopkins University, Baltimore, Maryland, USA.

出版信息

Surg Pathol Clin. 2015 Dec;8(4):561-80. doi: 10.1016/j.path.2015.08.003. Epub 2015 Oct 21.

DOI:10.1016/j.path.2015.08.003

PMID:26612215

Abstract

A wide array of molecular markers and genomic signatures, reviewed in this article, may soon be used as adjuncts to currently established screening strategies, prognostic parameters, and early detection markers. Markers of genetic susceptibility to PCA, recurrent epigenetic and genetic alterations, including ETS gene fusions, PTEN alterations, and urine-based early detection marker PCA3, are discussed. Impact of recent genome-wide assessment on our understanding of key pathways of PCA development and progression and their potential clinical implications are highlighted.

摘要

本文所综述的一系列分子标志物和基因组特征，可能很快会被用作当前既定筛查策略、预后参数和早期检测标志物的辅助手段。文中讨论了前列腺癌（PCA）遗传易感性的标志物、复发性表观遗传和基因改变，包括ETS基因融合、PTEN改变以及基于尿液的早期检测标志物PCA3。强调了近期全基因组评估对我们理解PCA发生和发展的关键途径及其潜在临床意义的影响。