胰腺切除术后胰岛素和胰高血糖素的分泌。剩余胰腺分泌与激素含量的相关性。

Insulin and glucagon secretion after pancreatectomies. Correlation of secretion and hormonal contents of remaining pancreas.

作者信息

Gotoh M, Monden M, Okamura J, Mori T, Shima K

机构信息

Second Department of Surgery, Osaka University Medical School, Japan.

出版信息

Diabetes. 1989 Jul;38(7):861-7. doi: 10.2337/diab.38.7.861.

DOI:10.2337/diab.38.7.861

PMID:2661285

Abstract

We studied whether insulin and glucagon secretory capacities change in relation to the corresponding hormonal contents in the pancreas remnant after pancreas resection. The following groups of dogs were used: sham operated (S-O), left pancreatectomized (L-Px), right pancreatectomized (R-Px), subtotal pancreatectomized (St-Px), and total pancreatectomized (T-Px). Endocrine functions were assessed by intravenous glucose tolerance test (IVGTT) and insulin tolerance test (ITT) in each dog under anesthesia before surgery and 1 wk after. In these five groups, the insulin secretory capacities, assessed as the integrated incremental secretion of immunoreactive insulin (sigma delta IRI) from the IVGTT, decreased to 95 +/- 11, 78 +/- 9, 48 +/- 8, 12 +/- 8, and -4 +/- 4% of the respective preoperative values, and these values were proportional to the percentage residual weight (100, 64 +/- 2, 35 +/- 2, 13 +/- 2, 0%) and IRI content (100, 59 +/- 4, 45 +/- 3, 10 +/- 2, 0%) of the pancreas remnant. After surgery, glucagon secretory capacity, the integrated incremental secretion of immunoreactive glucagon (sigma delta IRG) during the ITT, decreased significantly in the L-Px, St-Px, and T-Px groups but not in the R-Px group. The sigma delta IRG values as percentages of the preoperative values were 109 +/- 25, 46 +/- 11, 89 +/- 13, 19 +/- 11, and 3 +/- 3%, respectively, for the five groups. These values were proportional to the percentage residual IRG contents of the pancreas remnants (100, 48 +/- 6, 65 +/- 8, 12 +/- 2, 0%) rather than to the percentage residual pancreatic weights.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

我们研究了胰腺切除术后胰腺残端中胰岛素和胰高血糖素的分泌能力是否与其相应的激素含量相关。使用了以下几组犬：假手术组（S - O）、左胰腺切除组（L - Px）、右胰腺切除组（R - Px）、次全胰腺切除组（St - Px）和全胰腺切除组（T - Px）。在麻醉状态下，于术前及术后1周对每只犬通过静脉葡萄糖耐量试验（IVGTT）和胰岛素耐量试验（ITT）评估内分泌功能。在这五组中，IVGTT中以免疫反应性胰岛素的综合增量分泌（σΔIRI）评估的胰岛素分泌能力分别降至术前值的95±11%、78±9%、48±8%、12±8%和 - 4±4%，这些值与胰腺残端的残余重量百分比（100%、64±2%、35±2%、13±2%、0%）和IRI含量百分比（100%、59±4%、45±3%、10±2%、0%）成比例。术后，ITT期间免疫反应性胰高血糖素的综合增量分泌（σΔIRG）即胰高血糖素分泌能力在L - Px、St - Px和T - Px组中显著降低，但在R - Px组中未降低。五组的σΔIRG值相对于术前值的百分比分别为109±25%、46±11%、89±13%、19±11%和3±3%。这些值与胰腺残端的残余IRG含量百分比（100%、48±6%、65±8%、12±2%、0%）成比例，而非与胰腺残余重量百分比成比例。（摘要截短于250字）