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微小RNA-20b在肝细胞癌中的表达及其对缺氧诱导因子-1α和血管内皮生长因子的调控对细胞生物学行为的临床病理意义

Clinicopathological Significance of MicroRNA-20b Expression in Hepatocellular Carcinoma and Regulation of HIF-1α and VEGF Effect on Cell Biological Behaviour.

作者信息

Xue Tong-Min, Tao Li-de, Zhang Miao, Zhang Jie, Liu Xia, Chen Guo-Feng, Zhu Yi-Jia, Zhang Pei-Jian

机构信息

Institute of General Surgical Research, Second Affiliated Hospital, Yangzhou University, Yangzhou, Jiangsu 225002, China.

Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China.

出版信息

Dis Markers. 2015;2015:325176. doi: 10.1155/2015/325176. Epub 2015 Nov 3.

DOI:10.1155/2015/325176
PMID:26612965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4646993/
Abstract

miRNA-20b has been shown to be aberrantly expressed in several tumor types. However, the clinical significance of miRNA-20b in the prognosis of patients with hepatocellular carcinoma (HCC) is poorly understood, and the exact role of miRNA-20b in HCC remains unclear. The aim of the present study was to investigate the association of the expression of miR-20b with clinicopathological characteristics and overall survival of HCC patients analyzed by Kaplan-Meier analysis and Cox proportional hazards regression models. Meanwhile, the HIF-1α and VEGF targets of miR-20b have been confirmed. We found not only miR-20b regulation of HIF-1α and VEGF in normal but also regulation of miR-20b in hypoxia. This mechanism would help the tumor cells adapt to the different environments thus promoting the tumor invasion and development. The whole study suggests that miR-20b, HIF-1α, and VEGF serve as a potential therapeutic agent for hepatocellular carcinoma.

摘要

已证明miRNA - 20b在多种肿瘤类型中异常表达。然而，miRNA - 20b在肝细胞癌（HCC）患者预后中的临床意义尚不清楚，其在HCC中的确切作用仍不明确。本研究的目的是通过Kaplan - Meier分析和Cox比例风险回归模型，研究miR - 20b表达与HCC患者临床病理特征及总生存期的相关性。同时，已证实miR - 20b的HIF - 1α和VEGF靶点。我们发现，不仅miR - 20b在正常情况下对HIF - 1α和VEGF有调控作用，而且在缺氧条件下对miR - 20b也有调控作用。这种机制有助于肿瘤细胞适应不同环境，从而促进肿瘤侵袭和发展。整个研究表明，miR - 20b、HIF - 1α和VEGF可作为肝细胞癌的潜在治疗药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b38/4646993/ce24a6bd347f/DM2015-325176.009.jpg
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