急性疼痛向慢性疼痛的转变：慢性疼痛能否预防？
The Acute to Chronic Pain Transition: Can Chronic Pain Be Prevented?
作者信息
Pozek John-Paul J, Beausang David, Baratta Jaime L, Viscusi Eugene R
机构信息
Department of Anesthesiology, Thomas Jefferson University, Gibbon Building, Suite 8280, 111 South 11th Street, Philadelphia, PA 19107, USA.
Department of Anesthesiology, Thomas Jefferson University, Gibbon Building, Suite 8490, 111 South 11th Street, Philadelphia, PA 19107, USA.
出版信息
Med Clin North Am. 2016 Jan;100(1):17-30. doi: 10.1016/j.mcna.2015.08.005. Epub 2015 Oct 27.
Chronic postsurgical pain (CPSP) is a distressing disease process that can lead to long-term disability, reduced quality of life, and increased health care spending. Although the exact mechanism of development of CPSP is unknown, nerve injury and inflammation may lead to peripheral and central sensitization. Given the complexity of the disease process, no novel treatment has been identified. The preoperative use of multimodal analgesia has been shown to decrease acute postoperative pain, but it has no proven efficacy in preventing development of CPSP.
慢性术后疼痛（CPSP）是一种令人痛苦的疾病过程，可导致长期残疾、生活质量下降和医疗保健支出增加。尽管CPSP的确切发病机制尚不清楚，但神经损伤和炎症可能导致外周和中枢敏化。鉴于该疾病过程的复杂性，尚未确定新的治疗方法。术前使用多模式镇痛已被证明可减少术后急性疼痛，但在预防CPSP发生方面尚无经证实的疗效。
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