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当前预防急性术后疼痛向慢性转变的概念和目标。

Current concepts and targets for preventing the transition of acute to chronic postsurgical pain.

机构信息

Department of Anesthesia, University of Iowa Healthcare, Iowa City, Iowa.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, Florida, USA.

出版信息

Curr Opin Anaesthesiol. 2024 Oct 1;37(5):588-596. doi: 10.1097/ACO.0000000000001424. Epub 2024 Jul 31.

Abstract

PURPOSE OF REVIEW

It is estimated that approximately a third of patients undergoing certain surgeries may report some degree of persistent pain postoperatively. Chronic postsurgical pain (CPSP) reduces quality of life, is challenging to treat, and has significant socio-economic impact.

RECENT FINDINGS

From an epidemiological perspective, factors that predispose patients to the development of CPSP may be considered in relation to the patient, the procedure or, the care environment. Prevention or management of transition from acute to chronic pain often need a multidisciplinary approach beginning early in the preoperative period and continuing beyond surgical admission. The current concepts regarding the role of central and peripheral nervous systems in chronification of pain may provide targets for future therapies but, the current evidence seems to suggest that a multimodal analgesic approach of preventive analgesia along with a continued follow-up and treatment after hospital discharge may hold the key to identify and manage the transitioning of acute to chronic pain.

SUMMARY

A comprehensive multidisciplinary approach with prior identification of risk factors, minimizing the surgical insult and a culture of utilizing multimodal analgesia and continued surveillance beyond the period of hospitalization is an important step towards reducing the development of chronic pain. A transitional pain service model may accomplish many of these goals.

摘要

目的综述

据估计,大约有三分之一接受某些手术的患者术后可能会出现一定程度的持续性疼痛。慢性术后疼痛(CPSP)降低生活质量,治疗具有挑战性,并且具有重大的社会经济影响。

最新发现

从流行病学的角度来看,可以根据患者、手术或护理环境来考虑使患者易发生 CPSP 的因素。预防或管理从急性到慢性疼痛的转变通常需要多学科的方法,从术前早期开始,并在手术住院后继续进行。目前关于中枢和外周神经系统在疼痛慢性化中的作用的概念可能为未来的治疗提供靶点,但目前的证据似乎表明,预防性镇痛的多模式镇痛方法以及在出院后继续进行随访和治疗可能是确定和管理急性到慢性疼痛转变的关键。

总结

通过预先确定风险因素、最大限度地减少手术损伤以及采用多模式镇痛的文化,并在住院期间之外进行持续监测,采取全面的多学科方法是减少慢性疼痛发展的重要步骤。过渡性疼痛服务模式可能可以实现许多这些目标。

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