Jennings John D, Solarz Mark K, Haydel Christopher
Department of Orthopaedics and Sports Medicine, Temple University Hospital, 3401 North Broad Street, Zone B 5th Floor, Philadelphia, PA 19140, USA.
Department of Orthopaedics and Sports Medicine, Temple University Hospital, 3401 North Broad Street, Zone B 5th Floor, Philadelphia, PA 19140, USA.
Orthop Clin North Am. 2016 Jan;47(1):137-43. doi: 10.1016/j.ocl.2015.08.014.
Tranexamic acid has gained recent interest in orthopedics and trauma surgery because of its demonstrated benefit in several clinical trials. It is inexpensive and effective at reducing blood loss and blood transfusion requirements without a significant increase in morbidity or mortality. The optimal timing, dosing, and route of administration in orthopedics are yet to be elucidated. Significant investigation of tranexamic acid use in joint replacement and spine surgery has promoted its incorporation into the everyday practice of many of these surgeons. The paucity of studies regarding its use in orthopedic trauma has limited its integration into a field that may stand to benefit most from the drug.
由于在多项临床试验中已证实其益处，氨甲环酸最近在骨科和创伤外科领域受到关注。它价格低廉，在减少失血和输血需求方面有效，且不会显著增加发病率或死亡率。骨科中氨甲环酸的最佳使用时机、剂量和给药途径尚待阐明。对氨甲环酸在关节置换和脊柱手术中应用的大量研究促使许多外科医生将其纳入日常实践。关于其在骨科创伤中应用的研究匮乏，限制了它在这个可能最能从该药物中获益的领域的应用。
