脑深部电刺激治疗药物难治性癫痫的临床疗效

Clinical efficacy of deep brain stimulation for the treatment of medically refractory epilepsy.

作者信息

Klinger Neil V, Mittal Sandeep

机构信息

Department of Neurosurgery, Wayne State University, Detroit, MI, USA; Comprehensive Epilepsy Center, Wayne State University and Harper University Hospital, Detroit, MI, USA.

出版信息

Clin Neurol Neurosurg. 2016 Jan;140:11-25. doi: 10.1016/j.clineuro.2015.11.009. Epub 2015 Nov 14.

DOI:10.1016/j.clineuro.2015.11.009

PMID:26615464

Abstract

Epilepsy affects 50 million people worldwide and about 30% of these patients will not be adequately controlled with antiepileptic drugs (AEDs) alone. For patients where resective surgery is not indicated, deep brain stimulation (DBS) may be an effective alternative. The majority of available literature targets the thalamic nuclei (anterior; centromedian), subthalamic nucleus, hippocampus, and cerebellum. Here, we review patient outcomes and adverse events related to DBS to these various targets. Data show DBS may be a safe and effective treatment option for refractory epilepsy.

摘要

癫痫影响着全球5000万人，其中约30%的患者仅使用抗癫痫药物（AEDs）无法得到充分控制。对于不适合进行切除性手术的患者，深部脑刺激（DBS）可能是一种有效的替代方法。现有文献大多针对丘脑核（前核；中央中核）、丘脑底核、海马体和小脑。在此，我们回顾了针对这些不同靶点进行DBS治疗的患者预后和不良事件。数据表明，DBS可能是治疗难治性癫痫的一种安全有效的选择。