Johansen Claus
Department of Dermatology, Aarhus University Hospital, 8000 Aarhus C, Denmark.
Cytokine. 2016 Feb;78:20-1. doi: 10.1016/j.cyto.2015.11.015. Epub 2015 Nov 23.
Psoriasis is an immune-mediated chronic inflammatory skin disease with a complex etiology. The proinflammatory cytokine IL-17A is known to play key role in the pathogenesis of psoriasis, and recently anti-IL-17A antibodies have been approved for psoriasis treatment. Here, we discuss our recent findings demonstrating that IκBζ, a transcriptional co-activator, plays a crucial role in the development of psoriasis by mediating IL-17A-driven effects. These findings have significant implications as they uncover a novel crucial regulatory mechanism involved in psoriasis development, and identify IκBζ as a possible future target in the treatment of psoriasis and other IL-17A-driven diseases.
银屑病是一种病因复杂的免疫介导性慢性炎症性皮肤病。已知促炎细胞因子白细胞介素-17A（IL-17A）在银屑病发病机制中起关键作用，最近抗IL-17A抗体已被批准用于银屑病治疗。在此，我们讨论我们最近的发现，这些发现表明转录共激活因子IκBζ通过介导IL-17A驱动的效应在银屑病发展中起关键作用。这些发现具有重要意义，因为它们揭示了银屑病发展中涉及的一种新的关键调节机制，并将IκBζ确定为未来治疗银屑病和其他IL-17A驱动疾病的可能靶点。
