Department of Neurosurgery & Pathophysiology, Institute of Neuroregeneration & Neurorehabilitation, Qingdao University, Qingdao, China.
Department of Geriatrics, The Affiliated Hospital of Qingdao University, Qingdao, China.
Front Immunol. 2023 Jun 12;14:1188253. doi: 10.3389/fimmu.2023.1188253. eCollection 2023.
IκBζ (encoded by NFKBIZ) is the most recently identified IkappaB family protein. As an atypical member of the IkappaB protein family, NFKBIZ has been the focus of recent studies because of its role in inflammation. Specifically, it is a key gene in the regulation of a variety of inflammatory factors in the NF-KB pathway, thereby affecting the progression of related diseases. In recent years, investigations into NFKBIZ have led to greater understanding of this gene. In this review, we summarize the induction of NFKBIZ and then elucidate its transcription, translation, molecular mechanism and physiological function. Finally, the roles played by NFKBIZ in psoriasis, cancer, kidney injury, autoimmune diseases and other diseases are described. NFKBIZ functions are universal and bidirectional, and therefore, this gene may exert a great influence on the regulation of inflammation and inflammation-related diseases.
IκBζ（由 NFKBIZ 编码）是最近发现的 IκB 家族蛋白之一。作为 IκB 蛋白家族的一个非典型成员，NFKBIZ 因其在炎症中的作用而成为近期研究的焦点。具体来说，它是 NF-KB 通路中多种炎症因子调节的关键基因，从而影响相关疾病的进展。近年来，对 NFKBIZ 的研究加深了人们对该基因的认识。在这篇综述中，我们总结了 NFKBIZ 的诱导，并阐明了其转录、翻译、分子机制和生理功能。最后，描述了 NFKBIZ 在银屑病、癌症、肾损伤、自身免疫性疾病等疾病中的作用。NFKBIZ 的功能是普遍存在且双向的，因此，该基因可能对炎症和炎症相关疾病的调节产生重大影响。
