Kawase Koya, Sugiura Tokio, Nagaya Yoshiaki, Yamada Takaharu, Sugimoto Mari, Ito Koichi, Togawa Takao, Nagasaki Rika, Kato Takenori, Kouwaki Masanori, Koyama Norihisa, Saitoh Shinji
Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Department of Pediatrics, Toyohashi Municipal Hospital, Aichi, Japan.
Pediatr Int. 2016 Jun;58(6):461-6. doi: 10.1111/ped.12861. Epub 2016 Feb 3.
Persistent patent ductus arteriosus (PDA) is a frequent complication in preterm infants. Single nucleotide polymorphisms (SNP) in several genes, including angiotensin II receptor, type 1 (AGTR1), transcription factor AP-2 beta (TFAP2B) and tumor necrosis factor receptor-associated factor 1 (TRAF1), have been reported to be associated with PDA in preterm infants. The aim of this study was to evaluate the relationships between PDA in preterm infants and polymorphisms in AGTR1, TFAP2B and TRAF1 in the Japanese population.
The subjects consisted of 107 preterm infants with gestational age <32 weeks. Extremely low-birthweight infants were treated with prophylactic indomethacin during the first 24 h after birth. Five SNP, namely, rs5186 in AGTR1, rs987237 and rs6930924 in TFAP2B, and rs1056567 and rs10985070 in TRAF1, were genotyped using TaqMan SNP genotyping assays.
There were no significant differences in the distributions of the genotypes and allele frequencies of all studied SNP between the PDA group (n = 46) and the non-PDA group (n = 61).
There were no significant associations between the studied SNP and the incidence of PDA in Japanese preterm infants. These SNP may not be clinically important predisposing factors for PDA in Japanese preterm infants.
持续性动脉导管未闭（PDA）是早产儿常见的并发症。据报道，包括血管紧张素II受体1型（AGTR1）、转录因子AP-2β（TFAP2B）和肿瘤坏死因子受体相关因子1（TRAF1）在内的多个基因中的单核苷酸多态性（SNP）与早产儿PDA有关。本研究的目的是评估日本人群中早产儿PDA与AGTR1、TFAP2B和TRAF1基因多态性之间的关系。
研究对象包括107例孕周<32周的早产儿。极低出生体重儿在出生后24小时内接受预防性吲哚美辛治疗。使用TaqMan SNP基因分型检测对AGTR1中的rs5186、TFAP2B中的rs987237和rs6930924以及TRAF1中的rs1056567和rs10985070这5个SNP进行基因分型。
PDA组（n = 46）和非PDA组（n = 61）之间，所有研究SNP的基因型和等位基因频率分布均无显著差异。
在日本早产儿中，所研究的SNP与PDA的发生率之间无显著关联。这些SNP可能不是日本早产儿PDA的重要临床易感因素。
