Clifton G G, Anderson C, McMahon G, Vargas R, Wallin J D
Tulane University School of Medicine, Department of Medicine, New Orleans, Louisiana 70112.
J Clin Pharmacol. 1989 May;29(5):466-71. doi: 10.1002/j.1552-4604.1989.tb03364.x.
Glomerular filtration rate and effective renal plasma flow were measured in 170 subjects using monoexponential analysis of plasma disappearance curves for 99mTc-DTPA and 131I-iodohippurate after single injection. In the current study population, glomerular filtration rate and effective renal plasma flow decreased with increasing age, were less in females than in males, and were less in hypertensives than in normotensives. Differences in glomerular filtration rate according to age and sex in the current study were similar to those reported using traditional creatinine clearance methodology. Monoexponential treatment of plasma isotope disappearance gave reproducible values for both glomerular filtration rate and effective renal plasma flow when measured either during the day or on a daily basis. Intraindividual coefficient of variation was less than 10% for both 99mTc-DTPA and 131I-iodohippurate clearances derived from monoexponential analysis. These results demonstrate that monoexponential analysis of plasma disappearance curves for 99mTc-DTPA and 131I-iodohippurate after a single injection is a useful method for evaluating changes in renal hemodynamics either during chronic drug therapy or acutely after single dose administration.
对170名受试者单次注射99mTc - DTPA和131I - 碘马尿酸后，通过对血浆消失曲线进行单指数分析来测量肾小球滤过率和有效肾血浆流量。在当前的研究人群中，肾小球滤过率和有效肾血浆流量随年龄增长而下降，女性低于男性，高血压患者低于血压正常者。在本研究中，根据年龄和性别得出的肾小球滤过率差异与使用传统肌酐清除率方法报告的结果相似。对血浆同位素消失进行单指数处理时，无论是在白天测量还是每日测量，肾小球滤过率和有效肾血浆流量均可得到可重复的值。从单指数分析得出的99mTc - DTPA和131I - 碘马尿酸清除率的个体内变异系数均小于10%。这些结果表明，单次注射后对99mTc - DTPA和131I - 碘马尿酸的血浆消失曲线进行单指数分析，是评估慢性药物治疗期间或单次给药后急性肾血流动力学变化的一种有用方法。
