Robbins M E
Int J Appl Radiat Isot. 1984 Feb;35(2):85-91. doi: 10.1016/0020-708x(84)90189-3.
Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were determined in 32 anaesthetised female Large pigs, aged 4-24 months, from the plasma disappearance curves of [99mTc]DTPA and [131I]hippuran respectively. Clearance was also monitored by external counting over the heart. GFR and ERPF increased markedly with age in pigs up to 12 months old, reaching mean values of 242.06 +/- 5.89 and 919.39 +/- 79.01 mL/min. In pigs aged 12-24 months ERPF increased slightly, but renal function remained essentially unchanged after 1 yr of age. These results for renal function were similar to previous estimates, using continuous infusion techniques inferring that GFR and ERPF could be accurately monitored using single injection procedures.
分别根据[99mTc]二乙三胺五乙酸（DTPA）和[131I]马尿酸的血浆消失曲线，对32只4至24月龄的麻醉雌性大型猪测定了肾小球滤过率（GFR）和有效肾血浆流量（ERPF）。还通过心脏外部计数监测清除率。在12月龄以下的猪中，GFR和ERPF随年龄显著增加，平均分别达到242.06±5.89和919.39±79.01 mL/分钟。在12至24月龄的猪中，ERPF略有增加，但1岁以后肾功能基本保持不变。这些肾功能结果与先前使用连续输注技术的估计结果相似，表明使用单次注射程序可以准确监测GFR和ERPF。
